Erythritol: Potential Risks of the Popular Sugar Substitute

Why this matters: These findings raise concerns about the safety of erythritol, especially for individuals who consume it regularly as a sugar alternative. It highlights the need for further research and cautious consumption.

Erythritol, a sugar alcohol often derived from fermented corn, has gained popularity as a low-calorie sweetener with minimal impact on insulin levels. It is commonly found in sugar-free and keto-friendly foods. A study from the University of Colorado Boulder published in the *Journal of Applied Physiology* found that erythritol can harm brain blood vessel cells, potentially promoting constriction, clotting, and inflammation. Researchers exposed blood-brain barrier cells to erythritol levels typically found after consuming a sweetened beverage and observed a cascade of cell damage. This damage can make the brain more vulnerable to blood clots, a leading cause of stroke.

The study also found that erythritol reduces nitric oxide, which relaxes blood vessels, and increases endothelin-1, which constricts them. This imbalance can lead to dangerously constricted blood vessels, potentially depriving the brain of oxygen and nutrients. Furthermore, erythritol appeared to inhibit the body's natural clot-busting mechanism. Several observational studies have linked regular erythritol consumption to a higher risk of cardiovascular disease, including heart attacks and strokes. One study found that individuals with the highest blood levels of erythritol were approximately twice as likely to experience a major cardiac event.

While regulatory agencies have approved erythritol as safe for consumption, this new research contributes to a growing body of evidence suggesting that even "natural" sugar alternatives may carry unexpected health risks. Consumers may want to reconsider their relationship with erythritol and question whether any sugar substitute is truly without risk.

Erythritol is a sugar alcohol used as a low-calorie sweetener in many food products.

Recent studies suggest erythritol may damage the blood-brain barrier, increase stroke risk, and negatively impact cardiovascular health.

Erythritol is found in many sugar-free and keto-friendly products, including protein bars, energy drinks, and low-carb ice cream.

It may be prudent to monitor your consumption of non-nutrient sweeteners such as erythritol, especially if you have risk factors for heart disease or stroke. Consult with a healthcare professional for personalized advice.

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