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A study published in the Journal of Applied Physiology found that erythritol can harm brain blood vessel cells, promoting constriction, clotting, and inflammation.
Higher circulating levels of erythritol have been linked to an increased risk of heart attack or stroke within three years, according to a study involving 4,000 people.
Erythritol-treated cells expressed less nitric oxide (a molecule that widens blood vessels) and more endothelin-1 (a protein that constricts blood vessels).
The cells' ability to break down blood clots was also significantly reduced, and they produced more free radicals, which can damage cells and inflame tissue.
Why does this matter? These findings suggest that regular consumption of erythritol, especially in multiple servings per day, could increase the risk of stroke and other cardiovascular issues. Consumers, particularly those with obesity or diabetes who often use erythritol, should be aware of these potential risks.
Erythritol, a sugar alcohol produced by fermenting corn, has become a popular ingredient in sugar-free products due to its low-calorie content and minimal impact on insulin levels. It has been approved by the FDA since 2001.
The new study treated human brain blood vessel cells with erythritol amounts equivalent to a typical sugar-free beverage. The results indicated several adverse changes, including reduced nitric oxide production and increased endothelin-1, leading to constricted blood vessels. The cells' ability to break down clots was also impaired.
While the study was conducted on cells in a lab, the researchers advise caution. Christopher DeSouza, a senior author of the study, encourages consumers to read labels and monitor their intake of non-nutritive sweeteners like erythritol. This research underscores the importance of further studies to fully understand the long-term effects of erythritol consumption on human health.
What is erythritol?
Erythritol is a sugar alcohol used as a sugar substitute in many low-carb and sugar-free products.
What are the potential health risks of erythritol?
Recent studies suggest erythritol may be linked to brain cell damage, increased stroke risk, and other cardiovascular issues.
How much erythritol is considered harmful?
Even small amounts of erythritol, equivalent to a typical sugar-free beverage, have shown adverse effects on brain blood vessel cells in laboratory studies.
Be mindful of erythritol consumption, especially if you have risk factors for heart disease or stroke.
Read labels carefully and look for erythritol or "sugar alcohol" in the ingredients list.
Consider alternative sweeteners and consult with a healthcare professional for personalized advice.
Further research is needed to fully understand the long-term effects of erythritol on human health.
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