White Sox vs. Padres: Series Preview, Predictions, and Lineup Changes (May 1, 2026)

Background

The Padres (19-11) are coming off a series loss to the Cubs but have generally overachieved in April. The White Sox (14-17) are entering the series on a high note after sweeping the Los Angeles Angels.

Pitching Matchup

Noah Schultz (1-1, 3.52 ERA) will start for the White Sox. German Marquez (3-1, 4.38 ERA) takes the mound for the Padres. Marquez needs a strong performance to maintain his rotation spot, with Griffin Canning and Lucas Giolito nearing their debuts.

Lineup Changes

Jackson Merrill and Jake Cronenworth are out of the Padres' lineup. Bryce Johnson will start in center field, while Miguel Andujar moves up in the batting order.

Betting Odds & Predictions

Prediction: White Sox 5, Padres 4. Despite being underdogs, the White Sox are favored due to their recent form and Schultz's pitching prowess.

How to Watch

The game starts at 9:40 p.m. ET and will be broadcast on Padres.TV and the MLB app. Cable options include Cox (Channel 83), DirecTV (Channel 694-3), AT&T Uverse (Channel 781 or 1781), and Spectrum (Channel 305 or 443).

They are out due to the left-handed pitcher starting for the White Sox.

The game will be broadcast on Padres.TV and the MLB app, as well as select cable channels.

The White Sox vs. Padres series presents an intriguing matchup with the White Sox entering as the hotter team despite being the underdogs. Keep an eye on the pitching performance of both Schultz and Marquez, as well as how the Padres adjust to their lineup changes. This series could be a turning point for both teams as they head further into the season.

Do you think the White Sox can continue their winning streak against the Padres? Let us know your predictions! Share this article with others who need to stay ahead of this trend!