Matchup:: Baltimore Orioles vs. Toronto Blue Jays
Date & Time:: Thursday, March 27th, 2025, 3:07 p.m. ET
Location:: Rogers Centre, Toronto
Starting Pitchers:: Zach Eflin (BAL) vs. José Berríos (TOR)
Key Injuries:: Orioles SS Gunnar Henderson (intercostal strain) starts on IL; Blue Jays OF Daulton Varsho (shoulder) also out.
Why this matters:: Both teams are vying for position in the tough AL East and potential Wild Card spots. Early season wins against divisional rivals can be crucial down the stretch.
Odds:: Orioles enter as slight favorites (-115 moneyline).
The Orioles hand the ball to right-hander Zach Eflin, acquired mid-season in 2024 from Tampa Bay. Eflin posted a strong 2.60 ERA in nine starts for Baltimore after the trade and looks to anchor the rotation, especially with several key pitchers starting the year injured. Facing him is Toronto's reliable José Berríos, known for his consistency and durability (32 starts annually). Berríos handled the Orioles well last season (2.77 ERA in 13 IP), relying on inducing weak contact.
Orioles: With star shortstop Gunnar Henderson sidelined, Colton Cowser likely moves to leadoff, and top prospect Jackson Holliday may shift to shortstop. Baltimore hopes hot spring performances from Cowser (.364 AVG), Adley Rutschman (.357 AVG), and Ryan Mountcastle (5 HR) carry over. Félix Bautista's return from Tommy John surgery bolsters the bullpen.
*Likely Lineup:* Cowser (LF), Rutschman (C), Westburg (2B), O'Hearn (DH), O'Neill (RF), Mountcastle (1B), Mullins (CF), Urías (3B), Holliday (SS)
Blue Jays: Toronto's lineup features sluggers Vladimir Guerrero Jr. and Bo Bichette, with newly acquired Anthony Santander adding power. Guerrero Jr. (.323 AVG, 30 HR, 103 RBI in 2024) aims for another big year. The DH spot remains flexible. Their bullpen is led by new closer Jeff Hoffman but faces early depth challenges due to injuries.
*Likely Lineup:* Bichette (SS), Guerrero Jr. (1B), Santander (RF), Springer (LF), Giménez (2B), Kirk (C), Wagner (DH), Clement (3B), Straw (CF)
Orioles:: Henderson (intercostal) is the biggest immediate loss, though eligible to return April 3rd. The rotation is missing Grayson Rodriguez (elbow), Kyle Bradish (Tommy John), and Tyler Wells (UCL repair).
Blue Jays:: Daulton Varsho (shoulder) needs a few more weeks. Bullpen arms Erik Swanson, Ryan Burr, and Zach Pop are out. Max Scherzer's thumb is being monitored.
This is the first time the Orioles open their season in Toronto. The teams previously met on Opening Day only once, a 3-2 Orioles win in Baltimore in 2017.
When is the Orioles vs. Blue Jays Opening Day game?
Thursday, March 27th, 2025, with first pitch scheduled for 3:07 p.m. ET.
How can I watch the game?
The game is available on MLB.TV (stream), MASN2 (Orioles broadcast), Sportsnet/TVA Sports (Blue Jays broadcast, stream via Sportsnet+), and FuboTV (stream, offers free trial).
Who are the starting pitchers?
Zach Eflin for the Orioles and José Berríos for the Blue Jays.
Are there any major injuries affecting the lineups?
Yes, Orioles shortstop Gunnar Henderson is starting the season on the injured list with an intercostal strain. Blue Jays outfielder Daulton Varsho is also out, recovering from shoulder surgery.
AL East Intensity:: This game immediately highlights the competitiveness of the division. Every game matters.
Impact of Injuries:: Watch how both teams adapt to key absences, particularly Henderson for the Orioles' offense/defense and the impact on Toronto's bullpen depth.
Key Players to Watch:: Focus on how stars like Guerrero Jr., Bichette, Rutschman perform, and how newcomers/returning players like Eflin, Santander, and Bautista contribute.
Early Season Indicator:: While just one game, it provides an early glimpse into team strategies and potential season trajectories.
Both teams have playoff aspirations but face challenges. Do you think the Orioles can overcome their pitching injuries to contend? Will this be the last hurrah for the Blue Jays' current core?
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