Atlético de Madrid aims to leverage their home advantage in the first leg.
Tottenham is currently facing a crisis, struggling in the Premier League and with a new manager.
Key players for Atlético include Julián Álvarez, while Tottenham relies on Dominic Solanke.
Atlético advanced by defeating Brujas, while Tottenham secured their spot through the league stage.
The match is scheduled for March 10 and will be broadcast on ESPN and Disney+ Premium.
Atlético de Madrid enters the match after a mixed run, including a win against Real Sociedad (3-2) and a loss to Barcelona (0-3). They advanced in the Champions League by overcoming Brujas with a 7-4 aggregate score.
Tottenham's situation is more precarious, with five consecutive Premier League defeats and a recent change in management. They are dangerously close to the relegation zone.
Atlético de Madrid:: Julián Álvarez is their main attacking threat.
Tottenham:: Dominic Solanke is crucial for Tottenham's scoring opportunities.
The teams last met in 2016 at the International Champions Cup, where Atlético Madrid won 1-0 with a goal from Diego Godín.
Atlético de Madrid (4-4-2):: Jan Oblak; Matteo Ruggeri, David Hancko, José María Giménez, Nahuel Molina; Thiago Almada, Koke, Johnny Cardoso, Giuliano Simeone; Ademola Lookman, Julián Álvarez.
Tottenham (3-4-2-1):: Guglielmo Vicario; Micky van de Ven, Kevin Danso, Pedro Porro; Souza, Pape Sarr, João Palhinha, Archie Gray; Mathys Tel, Randal Kolo Muani; Dominic Solanke.
The match will be broadcast on ESPN and available for streaming on Disney+ Premium.
Q: When and where is the match being played?
The match is on March 10 at the Metropolitano Stadium in Madrid.
Q: How can I watch the game?
It will be broadcast on ESPN and streamed on Disney+ Premium.
Atlético Madrid is favored to win the first leg at home.
Tottenham is in a difficult form, struggling in their domestic league.
Key players like Julián Álvarez and Dominic Solanke will be crucial for their respective teams.
The match promises to be an engaging encounter, with Atlético seeking to capitalize on Tottenham's struggles.
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