Novak Djokovic faces Zizou Bergs for the first time. Djokovic is chasing a record-extending 41st Masters title.
Holger Rune will play against Valentin Vacherot, who is making an improbable run in Shanghai.
Betting odds favor Djokovic to win the Shanghai Masters, followed by Alex de Minaur and Felix Auger-Aliassime.
Bergs upset multiple ranked opponents to reach the quarterfinals.
Vacherot, ranked No. 204, qualified for the main draw and has been on a dream run.
Novak Djokovic vs. Zizou Bergs:
Djokovic, a four-time champion in Shanghai, faces Bergs, who is making his first appearance past the third round of a Masters 1000 event. Djokovic has shown moments of vulnerability, dropping sets in earlier matches, but remains the strong favorite.
Holger Rune vs. Valentin Vacherot:
Rune, with more experience at this level, faces Vacherot, who has had a surprising run to the quarterfinals. Rune has defeated two big servers in a row and is expected to continue his form.
Q: When will Djokovic face Bergs?
Thursday at 6:30 a.m. ET.
Q: Where is the Shanghai Masters being held?
Qi Zhong Stadium, Shanghai, China.
Djokovic is the favorite to win the Shanghai Masters.
Keep an eye on underdogs Bergs and Vacherot, who have shown surprising form.
Rune is expected to advance against Vacherot.
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