Fantasy Football Injury Report: Week 1 (2025)

Key Insights

• **Lamar Jackson (QB, BAL):** Recovered from a foot injury and is expected to be ready for Week 1.
• **Jaydon Blue (RB, DAL):** Dealing with a low-ankle sprain, but hasn’t been ruled out for Week 1.
• **Joe Mixon (RB, HOU):** Ankle injury with uncertain status for the season; will be re-evaluated in four weeks. Texans GM says they will take it "one day at a time." Why this matters: this creates uncertainty for fantasy managers relying on Mixon.
• **Najee Harris (RB, LAC):** Has an eye injury; a possibility to play in Week 1, but remains to be seen.
• **De’Von Achane (RB, MIA):** Expected to play Week 1 despite a calf injury. Why this matters: Calf strains for RBs typically resolve in under three weeks.
• **Tyjae Spears (RB, TEN):** Placed on IR with a high-ankle sprain.
• **MarShawn Lloyd (RB, GB):** Placed on IR with a hamstring injury; will miss at least four games.
• **Jalen Coker (WR, CAR):** Placed on IR with a quad injury and will miss at least four games.
• **Jalen McMillan (WR, TB):** Placed on IR with a neck injury, potentially out until Week 10.
• **Malik Nabers (WR, NYG):** Dealt with multiple minor injuries but returned to practice on August 26th.
• **Brandon Aiyuk (WR, SF):** Placed on the PUP list with a knee injury; expected return around Week 6.
• **Chris Godwin (WR, TB):** Ankle injury, likely to return in Week 5.
• **Jauan Jennings (WR, SF):** Calf injury; status for Week 1 is uncertain.
• **Marvin Mims Jr. (WR, DEN):** Groin injury; expected to return to practice on September 1st.
• **Darnell Mooney (WR, ATL):** Practiced for the first time since July 24th after a shoulder injury; Week 1 status is unknown.
• **Khalil Shakir (WR, BUF):** Expected to be available for Week 1 despite a high-ankle sprain.
• **Tetairoa McMillan (WR, CAR):** Hamstring soreness; returned to practice on August 26th.
• **Christian Watson (WR, GB):** Placed on the PUP list and will miss at least four games due to a torn ACL.
• **DeVonta Smith (WR, PHI):** Dealt with groin and back injuries; Week 1 status appears secure but keep monitoring.
• **A.J. Brown (WR, PHI):** Practiced consecutive days last week after dealing with a hamstring injury.
• **Tory Horton (WR, SEA):** Optimistic to be active in Week 1 despite an ankle injury.
• **Cade Otton (TE, TB):** Leg injury; unlikely to be ready for Week 1.
• **Isaiah Likely (TE, BAL):** Foot injury requiring surgery; expected back in the early portion of the season.
• **Matthew Stafford (QB, LAR):** Back injury; projected to be active Week 1.