Chicago Cubs vs. St. Louis Cardinals: Game Preview & Betting Insights

In-Depth Analysis

The Cardinals vs. Cubs game on September 26, 2025, features a pitching matchup between Miles Mikolas and a yet-to-be-announced Cubs starter (likely Javier Assad). Mikolas has struggled this season with a 4.76 ERA, while Assad has similar numbers, suggesting neither pitcher is likely to dominate.

**Cardinals' Offense:** St. Louis is leaning on hitters like Donovan and Burleson, who perform well against right-handed pitchers. However, their overall offensive approach has been inconsistent.

**Cubs' Offense:** The Cubs' offense has shown improvement in September, ranking ninth in wRC+. With the potential return of Kyle Tucker and the emergence of Moises Ballesteros, the Cubs could have a productive offensive day.

**Betting Analysis:** Given the pitching struggles and offensive potential, betting on 'Over 9' total runs seems like a favorable pick. The game is set to be broadcast on MLB Network.

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FAQ

- **Q: Who are the probable starting pitchers?

- **Q: What is the betting recommendation?

Takeaways

Expect a potentially high-scoring game based on the pitching matchups and offensive capabilities of both teams.
Keep an eye on Kyle Tucker's return to the Cubs' lineup and how he impacts their offensive performance.
Consider the betting insights when making your MLB wagers.

Discussion

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Sources

Chicago Cubs vs. St. Louis Cardinals preview, Friday 9/26, 1:20 CT Really, Cubs? You’re Taking This Long? Cubs vs Cardinals Series Preview St. Louis Cardinals vs Chicago Cubs Prediction, Pick, Odds -- 9/26

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