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49ers vs. Cardinals Week 11: Predictions, How to Watch, and Key Matchups
7 months agoUS
The San Francisco 49ers (6-4) travel to Arizona to face the Cardinals (3-6) in a Week 11 matchup. This article provides a comprehensive preview, including predictions from Niners Nation staff, how to watch and listen, and a key matchup analysis focusing on Cardinals tight end Trey McBride.
Key Insights
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Broadcast Information:: The game will be broadcast on FOX for fans in the orange areas shown on 506sports.com&ref=yanuki.com. Streaming options include NFL+ and Game Pass International on DAZN for international viewers.
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Predictions:: Niners Nation staff predict a 49ers victory with scores ranging from 27-17 to 31-23. The general consensus is that the 49ers offense, with the return of Brock Purdy and Ricky Pearsall, will be too much for the Cardinals defense.
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Key Matchup:: The 49ers defense will need to contain Cardinals tight end Trey McBride, who has become a focal point of their offense, especially with injuries to other key players.
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Injury Report:: The 49ers are getting healthier with the return of Purdy and Pearsall, while the Cardinals are missing key players like Marvin Harrison Jr. and Zay Jones.
In-Depth Analysis
How to Watch & Listen
The 49ers vs. Cardinals game kicks off at 1:05 p.m. PT on Sunday, November 16, 2025.
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Television:: Watch on FOX if you are in the broadcast area (check 506sports.com&ref=yanuki.com for coverage maps).
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Streaming:: NFL+ offers live local, primetime, regular season, and postseason games on your phone or tablet. International fans can use Game Pass International on DAZN&ref=yanuki.com.
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Radio:: Listen on KSFO (810 AM), The Bone (107.7 FM), and the 49ers Radio Network. Spanish broadcast available on the 49ers App and 49ers.com/esp&ref=yanuki.com.
Niners Nation Predictions
The Niners Nation team is confident in a 49ers victory, citing the team's improved health and the Cardinals' injury woes. The predictions highlight:
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Offensive Advantage:: The 49ers offense is expected to exploit the Cardinals' defense, particularly through the passing game with Pearsall.
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Defensive Pressure:: The 49ers' defensive line should be able to pressure Jacoby Brissett, especially with Bryce Huff back.
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Running Game:: Christian McCaffrey and Brian Robinson Jr. are expected to have success against the Cardinals' run defense.
Key Matchup: Trey McBride vs. 49ers Defense
Trey McBride has emerged as a primary target in the Cardinals' offense. With injuries to other key players, the 49ers' ability to contain McBride will be crucial. Defensive coordinator Robert Saleh has compared McBride to George Kittle, emphasizing his blocking and receiving abilities. Tatum Bethune noted the importance of getting McBride to the ground and fighting for 50/50 balls.
Additional Keys to Victory for the 49ers:
1.
Protect Brock Purdy and utilize his mobility.
2.
Establish the running game with Christian McCaffrey.
3.
Stop Jacoby Brissett on third down.
4.
Avoid turnovers.
FAQs
Where can I watch the 49ers vs. Cardinals game?
The game will be broadcast on FOX in select areas. You can also stream it on NFL+ or Game Pass International on DAZN.
What are the predictions for the game?
Niners Nation staff predict the 49ers will win, with scores ranging from 27-17 to 31-23.
Who is the key player to watch for the Cardinals?
Tight end Trey McBride, who has become a focal point of their offense.
Key Takeaways
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The 49ers are favored to win their Week 11 matchup against the Cardinals.
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The return of Brock Purdy and Ricky Pearsall should boost the 49ers' offense.
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Containing Trey McBride will be crucial for the 49ers' defense.
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Fans can watch the game on FOX (in select areas), NFL+, or Game Pass International on DAZN.
Discussion
Do you think the 49ers will cover the spread against the Cardinals? Let us know in the comments!
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